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Article

IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2000

Jones D E, Buxbaum L U, Scott P

Abstract excerpt

Leishmania amazonensis induces a nonhealing infection in C3H mice, whereas infection with Leishmania major is self-healing. We found that C3H mice infected with L. amazonensis exhibited decreased IL-12 production, which could account for the susceptibility to this organism. However, exogenous IL-12 administration failed to induce a healing immune response. The failure of L. amazonensis-infected C3H mice to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10861073
DOI: 10.4049/jimmunol.165.1.364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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