Article
Omp25-dependent engagement of SLAMF1 by Brucella abortus in dendritic cells limits acute inflammation and favours bacterial persistence in vivo.
Cellular microbiology - 1 Apr 2020
Degos Clara, Hysenaj Lisiena, Gonzalez-Espinoza Gabriela, Arce-Gorvel Vilma, Gagnaire Aurélie, Papadopoulos Alexia, Pasquevich Karina Alejandra, Méresse Stéphane, Cassataro Juliana, Mémet Sylvie, Gorvel Jean-Pierre
Abstract excerpt
The strategies by which intracellular pathogenic bacteria manipulate innate immunity to establish chronicity are poorly understood. Here, we show that Brucella abortus outer membrane protein Omp25 specifically binds the immune cell receptor SLAMF1 in vitro. The Omp25-dependent engagement of SLAMF1 by B. abortus limits NF-κB translocation in dendritic cells (DCs) with no impact on Brucella intracellular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.