Article
Toxoplasma gondii uses sulfated proteoglycans for substrate and host cell attachment.
Infection and immunity - 1 Jul 2000
Carruthers V B, Håkansson S, Giddings O K, Sibley L D
Abstract excerpt
Toxoplasma gondii is an obligate intracellular parasite that actively invades a wide variety of vertebrate cells, although the basis of this pervasive cell recognition is not understood. We demonstrate here that binding to the substratum and to host cells is partially mediated by interaction with sulfated glycosaminoglycans (GAGs). Addition of excess soluble GAGs blocked parasite attachment to serum-coated glass,...
Topics
- Animals
- Cell Adhesion
- Cell Line
- Fibroblasts
- Glycosaminoglycans
- Heparin Lyase
- Humans
- Ligands
- Mutation
- Proteoglycans
- Solubility
- Toxoplasma