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Article

Inactivation of Pasteurella (Mannheimia) haemolytica leukotoxin causes partial attenuation of virulence in a calf challenge model.

Infection and immunity - 1 Jul 2000

Highlander S K, Fedorova N D, Dusek D M, Panciera R, Alvarez L E, Rinehart C

Abstract excerpt

The leukotoxin of Pasteurella (Mannheimia) haemolytica is believed to play a significant role in pathogenesis, causing cell lysis and apoptosis that lead to the lung pathology characteristic of bovine shipping fever. Using a system for Cre-lox recombination, a nonpolar mutation within the lktC transacylase gene of the leukotoxin operon was created. The lktC locus was insertionally inactivated using a...

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Identifiers

PMID: 10858203
DOI: 10.1128/IAI.68.7.3916-3922.2000
PMCID: PMC101667

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