Article
Genetic linkage analysis of X-ray hypersensitivity in the LEC mutant rat.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2000
Agui T, Miyamoto T, Jung C G, Tsumagari T, Masuda K, Manabe T
Abstract excerpt
The LEC rat has been reported to exhibit X-ray hypersensitivity and deficiency in DNA double-strand break (DSB) repair. The present study was performed to map the locus responsible for this phenotype, the xhs (X-ray hypersensitivity), as the first step in identifying the responsible gene. Analysis of the progeny of (BN x LEC)F(1) x LEC backcrosses indicated that the X-ray hypersensitive phenotype was controlled...
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