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Article

The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation.

Development (Cambridge, England) - 1 Jul 2000

Bae S, Bessho Y, Hojo M, Kageyama R

Abstract excerpt

We have isolated the basic helix-loop-helix (bHLH) gene Hes6, a novel member of the family of mammalian homologues of Drosophila hairy and Enhancer of split. Hes6 is expressed by both undifferentiated and differentiated cells, unlike Hes1, which is expressed only by the former cells. Hes6 alone does not bind to the DNA but suppresses Hes1 from repressing transcription. In addition, Hes6 suppresses Hes1 from...

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Identifiers

PMID: 10851137
DOI: 10.1242/dev.127.13.2933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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