Article
HES6-1 and HES6-2 function through different mechanisms during neuronal differentiation.
PloS one - 2 Dec 2010
Vilas-Boas Filipe, Henrique Domingos
Abstract excerpt
BACKGROUND: Notch signalling plays a central role in the mechanisms regulating neuronal differentiation in the vertebrate nervous system. The transcriptional repressors encoded by Hes genes are the main effectors of this pathway, acting in neural progenitors during the lateral inhibition process to repress proneural genes and inhibit differentiation. However, Hes6 genes seem to behave differently: they are...
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