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Article

Expression of DUX4 in zebrafish development recapitulates facioscapulohumeral muscular dystrophy.

Human molecular genetics - 1 Feb 2013

Mitsuhashi Hiroaki, Mitsuhashi Satomi, Lynn-Jones Taylor, Kawahara Genri, Kunkel Louis M

Abstract excerpt

Facioscapulohumeral muscular dystrophy (FSHD) is a common form of muscular dystrophy characterized by an asymmetric progressive weakness and wasting of the facial, shoulder and upper arm muscles, frequently accompanied by hearing loss and retinal vasculopathy. FSHD is an autosomal dominant disease linked to chromosome 4q35, but the causative gene remains controversial. DUX4 is a leading candidate gene as...

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Source

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Identifiers

PMID: 23108159
DOI: 10.1093/hmg/dds467
PMCID: PMC3606007

Genes

DUX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Expression of DUX4 in zebrafish development recapitulates facioscapulohumeral muscular dystrophy.PMID 23108159Read ↗

<i>DUX4</i>, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53‐dependent myopathy in vivoSemantic proximity Read ↗

Facioscapulohumeral dystrophy: activating an early embryonic transcriptional program in human skeletal muscleSemantic proximity Read ↗

Transgenic mouse models for investigating human <i>DUX4</i> expression during development and its roles in FSHD pathophysiologySemantic proximity Read ↗

Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model.Semantic proximity Read ↗

Transgenic Drosophila for Investigating DUX4 and FRG1, Two Genes Associated with Facioscapulohumeral Muscular Dystrophy (FSHD).Semantic proximity Read ↗

Facioscapulohumeral Dystrophy: Molecular Basis and Therapeutic Opportunities.Semantic proximity Read ↗

Cellular and animal models for facioscapulohumeral muscular dystrophySemantic proximity Read ↗

Biphasic myopathic phenotype of mouse DUX, an ORF within conserved FSHD-related repeats.Semantic proximity Read ↗

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Influence of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Possible TreatmentsSemantic proximity Read ↗

Mouse Dux is myotoxic and shares partial functional homology with its human paralog DUX4Semantic proximity Read ↗

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