Article
Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2010
Goutagny Stéphane, Yang Hong Wei, Zucman-Rossi Jessica, Chan Jennifer, Dreyfuss Jonathan M, Park Peter J, Black Peter M, Giovannini Marco, Carroll Rona S, Kalamarides Michel
Abstract excerpt
PURPOSE: Meningiomas are the most common central nervous system tumors in the population of age 35 and older. WHO defines three grades predictive of the risk of recurrence. Clinical data supporting histologic malignant progression of meningiomas are sparse and underlying molecular mechanisms are not clearly depicted. EXPERIMENTAL DESIGN: We identified genetic alterations associated with histologic progression of...
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