Article
Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2007
Blednov Yuri A, Cravatt Benjamin F, Boehm Stephen L, Walker Danielle, Harris R Adron
Abstract excerpt
Endocannabinoid signaling plays the important role in regulation of ethanol intake. Fatty acid amide hydrolase (FAAH) is a key membrane protein for metabolism of endocannabinoids, including anandamide, and blockade of FAAH increases the level of anandamide in the brain. To determine if FAAH regulates ethanol consumption, we studied mutant mice with deletion of the FAAH gene. Null mutant mice showed higher...
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