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Article

Insulin resistance: a chicken that has come to roost.

Annals of the New York Academy of Sciences - 18 Nov 1999

Reaven G M

Abstract excerpt

Insulin-mediated glucose disposal varies approximately 10-fold in apparently healthy human beings. Insulin (I)-resistant individuals can remain glucose tolerant if the pancreas compensates for this defect by secreting large amounts of I. Type 2 diabetes develops when I-resistant persons cannot sustain this state of compensatory hyperinsulinemia (increases I). However, the ability of increases I to prevent...

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Identifiers

PMID: 10842651
DOI: 10.1111/j.1749-6632.1999.tb07784.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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