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Article

Evolutionary origins of insulin resistance: a behavioral switch hypothesis.

BMC evolutionary biology - 17 Apr 2007

Watve Milind G, Yajnik Chittaranjan S

Abstract excerpt

BACKGROUND: Insulin resistance, which can lead to a number of diseases including type 2 diabetes and coronary heart disease, is believed to have evolved as an adaptation to periodic starvation. The "thrifty gene" and "thrifty phenotype" hypotheses constitute the dominant paradigm for over four decades. With an increasing understanding of the diverse effects of impairment of the insulin signaling pathway, the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17437648
DOI: 10.1186/1471-2148-7-61
PMCID: PMC1868084

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Source receipt: pubmed, retrieved 7 Sept 2026.

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