Article
Structure and function of microplasminogen: reconstitution of microplasminogen and microplasmin from isolated fragments.
Ciba Foundation symposium - 1 Jan 1997
de los Santos T, Wang J, Reich E
Abstract excerpt
We describe limited chemical proteolysis of microplasminogen/microplasmin (mPlg/mPlm) and their reconstitution from isolated fragments. A V141-->M141 substitution in methionineless human mPlg/mPlm allowed the protein(s) to be cleaved in CNBr/formic acid. The resulting two fragments (141 and 118 r...
Topics
- Amino Acid Sequence
- Drug Stability
- Fibrinolysin
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Plasminogen
- Structure-Activity Relationship