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Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand.

Archives of biochemistry and biophysics - 15 Dec 2002

Vargo-Gogola Tracy, Crawford Howard C, Fingleton Barbara, Matrisian Lynn M

Abstract excerpt

Soluble Fas ligand (sFasL) is released from the cell surface by matrix metalloproteinases (MMPs), one of which is MMP-7. We have reported that MMP-7-generated sFasL is pro-apoptotic in both in vitro and in vivo systems. However, there are contradictory reports that the soluble form of FasL is inactive or anti-apoptotic, resulting in significant controversy in the literature. One potential explanation for these...

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PMID: 12464266
DOI: 10.1016/s0003-9861(02)00525-8

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