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Article

Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation.

FEBS letters - 26 May 2000

Ulens C, Tytgat J

Abstract excerpt

The S631C mutation in human ether-à-go-go-related gene (HERG) channels has previously been reported to disrupt C-type inactivation and ion-selectivity when Cys-631 is in the oxidized state. In this study, we report the relation between pharmacology and C-type inactivation for HERGS631C channels. We demonstrate that HERGS631C in its reduced state is fully blocked by 1 microM astemizole, terfenadine and dofetilide,...

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Identifiers

PMID: 10828461
DOI: 10.1016/s0014-5793(00)01586-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation.PMID 10828461Read ↗

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