Article
Bcl-6 mutation status provides clinically valuable information in early-stage B-cell chronic lymphocytic leukemia.
Leukemia - 1 Apr 2004
Sarsotti E, Marugan I, Benet I, Terol M J, Sanchez-Izquierdo D, Tormo M, Rubio-Moscardo F, Martinez-Climent J A, García-Conde J
Abstract excerpt
In B-cell chronic lymphocytic leukemia (B-CLL), somatic mutation of IgVH genes defines a subgroup with favorable prognosis, whereas the absence of IgVH mutations is correlated with a worse outcome. Mutations of the BCL-6 gene are also observed in a subset of B-CLL, but the clinical significance of this molecular alteration remains uncertain. We examined the distribution of IgVH and BCL-6 gene mutations in 95...
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