Article
Racial and ethnic factors in the genetic pathogenesis of colorectal cancer.
Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians - 1 Jan 1999
Carethers J M
Abstract excerpt
Colorectal cancer can develop by two distinct pathogenic mechanisms: one involving chromosomal breakage and aneuploidy (called chromosomal instability) and one involving mutations at DNA micro-satellite sequences (termed micro-satellite instability). Relatively few reports consider these mechanisms of colorectal cancer development across racial or ethnic groups. Available data indicate a moderate increase in...
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