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Article

Critical influences on the pathogenesis of follicular lymphoma.

Blood - 24 May 2018

Küppers Ralf, Stevenson Freda K

Abstract excerpt

The development of follicular lymphoma (FL) from a founder B cell with an upregulation of B-cell lymphoma 2 (BCL2), via the t(14;18) translocation, to a proliferating clone, poised to undergo further transformation to an aggressive lymphoma, illustrates the opportunistic Darwinian process of tumorigenesis. Protection against apoptosis allows an innocent cell to persist and divide, with dangerous accumulation of...

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Share to Disease Susceptibility
Share to Epigenesis, Genetic
Share to Lymphoma, Follicular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Grading

Share to Precancerous Conditions

Share to Protein Processing, Post-Translational

Share to Receptors, Antigen, B-Cell

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Source

Identifiers

PMID: 29666116
DOI: 10.1182/blood-2017-11-764365

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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