Article
Pathogenesis of follicular lymphoma: genetics to the microenvironment to clinical translation.
British journal of haematology - 1 Sept 2021
Kumar Emil, Pickard Lucy, Okosun Jessica
Abstract excerpt
Follicular lymphoma (FL) represents a heterogeneous disease both clinically and biologically. The pathognomonic t(14;18) translocation can no longer be thought of as the primary genetic driver, with increasing recognition of the biological relevance of recurrent genetic alterations in epigenetic regulators that now feature as a pivotal hallmark of this lymphoma subtype. Furthermore, sequencing studies have...
Topics
- Animals
- Epigenesis, Genetic
- Gene Expression Regulation, Neoplastic
- Humans
- Lymphoma, Follicular
- Mutation
- Translocation, Genetic
- Tumor Microenvironment