Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease.

doi:10.1002/mds.25132

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Article

Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2012

Kilarski Laura L, Pearson Justin P, Newsway Victoria, Majounie Elisa, Knipe M Duleeka W, Misbahuddin Anjum, Chinnery Patrick F, Burn David J, Clarke Carl E, Marion Marie-Helene, Lewthwaite Alistair J, Nicholl David J, Wood Nicholas W, Morrison Karen E, Williams-Gray Caroline H, Evans Jonathan R, Sawcer Stephen J, Barker Roger A, Wickremaratchi Mirdhu M, Ben-Shlomo Yoav, Williams Nigel M, Morris Huw R

Abstract excerpt

Approximately 3.6% of patients with Parkinson's disease develop symptoms before age 45. Early-onset Parkinson's disease (EOPD) patients have a higher familial recurrence risk than late-onset patients, and 3 main recessive EOPD genes have been described. We aimed to establish the prevalence of mutations in these genes in a UK cohort and in previous studies. We screened 136 EOPD probands from a high-ascertainment...

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Identifiers

PMID: 22956510
DOI: 10.1002/mds.25132

Genes

PINK1
PARK7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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