Article
Confirmation of the association between bleomycin hydrolase genotype and Alzheimer's disease.
Molecular psychiatry - 1 Mar 2000
Papassotiropoulos A, Bagli M, Jessen F, Frahnert C, Rao M L, Maier W, Heun R
Abstract excerpt
Bleomycin hydrolase (BH), a cysteine protease from the papain superfamily, is considered to be a candidate for the beta-secretase, which is presumably involved in the production of beta-amyloid peptide. The G/G genotype of BH was identified as a significant risk factor for the development of Alzheimer's disease (AD) in subjects not carrying the apolipoprotein E epsilon4 allele (apoE-epsilon4). However, this...
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