Article
Association between bleomycin hydrolase and Alzheimer's disease in caucasians.
Annals of neurology - 1 Nov 1998
Farrer L A, Abraham C R, Haines J L, Rogaeva E A, Song Y, McGraw W T, Brindle N, Premkumar S, Scott W K, Yamaoka L H, Saunders A M, Roses A D, Auerbach S A, Sorbi S, Duara R, Pericak-Vance M A, St George-Hyslop P H
Abstract excerpt
A recent study showed modest evidence for an increased frequency of the bleomycin hydrolase (BH) V/V genotype in Alzheimer's disease (AD) patients compared with non-demented controls. To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subje...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Boston
- Cysteine Endopeptidases
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- North Carolina
- Polymorphism, Genetic
- Reference Values