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Article

The Pitx2 protein in mouse development

1 May 2000

Abstract excerpt

The Rieger syndrome, an autosomal dominant disorder involving ocular, dental, and umbilical defects is caused by mutations in PITX2, a Bicoid-type homeobox protein. Mouse Pitx2 mRNA is expressed in eye, tooth and umbilicus consistent with the human Riegers phenotype. Moreover, Pitx2 is involved in the Nodal/Sonic hedgehog pathway that determines left/right polarity. In this report we demonstrate a 32-kDa...

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PMID: 10822271
DOI: 10.1002/(sici)1097-0177(200005)218:1<195::aid-dvdy17>3.0.co;2-c

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The Pitx2 protein in mouse developmentPMID 10822271Read ↗

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