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Dihydropteroate Synthase of <i>Mycobacterium leprae</i> and Dapsone Resistance

1 Jun 2000

Abstract excerpt

Two Mycobacterium leprae genes, folP1 and folP2, encoding putative dihydropteroate synthases (DHPS), were studied for enzymatic activity and for the presence of mutations associated with dapsone resistance. Each gene was cloned and expressed in a folP knockout mutant of Escherichia coli (C600DeltafolP::Km(r)). Expression of M. leprae folP1 in C600DeltafolP::Km(r) conferred growth on a folate-deficient medium, and...

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PMID: 10817704
DOI: 10.1128/aac.44.6.1530-1537.2000

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