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Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake

1 Jan 2008

Abstract excerpt

UNLABELLED: Fosmidomycin is a phosphonic antibiotic which inhibits 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr), the first committed step of the non-mevalonate pathway of isoprenoid biosynthesis. In Mycobacterium tuberculosis Dxr is encoded by Rv2870c, and although the antibiotic has been shown to inhibit the recombinant enzyme 1, mycobacteria are intrinsically resistant to fosmidomycin at the whole cell...

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PMID: 18489786
DOI: 10.1186/1471-2180-8-78

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