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Article

Stimulation of Bordetella pertussis adenylate cyclase toxin intoxication by its hemolysin domain.

Infection and immunity - 1 Jun 2000

Iwaki M, Kamachi K, Konda T

Abstract excerpt

The internalization of the N-terminal catalytic domain of Bordetella pertussis adenylate cyclase toxin (ACT) across the cytoplasmic membrane has been considered to occur independently from protein-protein interactions which can lead to oligomerization required for hemolytic activity by its C-terminal hemolysin domain. Here we report that when added in excess, this hemolysin domain stimulates the internalization,...

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Identifiers

PMID: 10816536
DOI: 10.1128/IAI.68.6.3727-3730.2000
PMCID: PMC97667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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