Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection.

doi:10.1016/0882-4010(92)90057-u

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Article

Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection.

Microbial pathogenesis - 1 Mar 1992

Khelef N, Sakamoto H, Guiso N

Abstract excerpt

Among virulence factors synthesized and secreted by Bordetella pertussis, pertussis toxin (PTX) and the bifunctional adenylate cyclase-hemolysin (AC-Hly) are able to invade mammalian cells and to impair intracellular functions. Moreover, both proteins are protective antigens in murine intracerebr...

Topics

Adenylate Cyclase Toxin
Adenylyl Cyclases
Animals
Antibodies, Bacterial
Bacterial Toxins
Bordetella pertussis
Female
Genes, Bacterial
Hemolysin Proteins
Mice
Mutation
Pertussis Toxin
Virulence
Virulence Factors, Bordetella
Whooping Cough

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