Article
In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterations in cytoplasmic membrane fluidity.
Infection and immunity - 1 Jun 2000
Bayer A S, Prasad R, Chandra J, Koul A, Smriti M, Varma A, Skurray R A, Firth N, Brown M H, Koo S P, Yeaman M R
Abstract excerpt
Platelet microbicidal proteins (PMPs) are small, cationic peptides which possess potent microbicidal activities against common bloodstream pathogens, such as Staphylococcus aureus. We previously showed that S. aureus strains exhibiting resistance to thrombin-induced PMP (tPMP-1) in vitro have an enhanced capacity to cause human and experimental endocarditis (T. Wu, M. R. Yeaman, and A. S. Bayer, Antimicrob....
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