Article
Phenotypic resistance to thrombin-induced platelet microbicidal protein in vitro is correlated with enhanced virulence in experimental endocarditis due to Staphylococcus aureus.
Infection and immunity - 1 Aug 1997
Dhawan V K, Yeaman M R, Cheung A L, Kim E, Sullam P M, Bayer A S
Abstract excerpt
Thrombin-induced platelet microbicidal protein (tPMP) is secreted by rabbit platelets following thrombin stimulation, and it kills common endovascular pathogens in vitro, including Staphylococcus aureus. Therefore, pathogens which exhibit tPMP resistance in vitro possess a potential survival adva...
Topics
- Animals
- Antimicrobial Cationic Peptides
- Bacteremia
- Blood Platelets
- Blotting, Southern
- Endocarditis, Bacterial
- Phenotype
- Proteins
- Rabbits
- Staphylococcal Infections
- Staphylococcus aureus
- Thrombin
- Virulence