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Plasmid-Mediated Resistance to Thrombin-Induced Platelet Microbicidal Protein in Staphylococci: Role of the qacA Locus

1 Oct 1999

Abstract excerpt

Thrombin-induced platelet microbicidal protein 1 (tPMP-1) is a small, cationic peptide released from rabbit platelets following thrombin stimulation. In vitro resistance to this peptide among strains of Staphylococcus aureus correlates with the survival advantage of such strains at sites of endothelial damage in humans as well as in experimental endovascular infections. The mechanisms involved in the phenotypic...

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PMID: 10508013
DOI: 10.1128/aac.43.10.2395

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Functional analyses reveal an important role for tyrosine residues in the staphylococcal multidrug efflux protein QacA.Semantic proximity Read ↗

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