Article
Correlation of genetic instability with mismatch repair protein expression and p53 mutations in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2000
Chang J W, Chen Y C, Chen C Y, Chen J T, Chen S K, Wang Y C
Abstract excerpt
To examine the etiological association of genetic instability in lung tumorigenesis, we investigated the frequency of microsatellite instability (MI) of eight dinucleotide repeat markers in 68 patients with non-small cell lung cancer. Twenty-eight patients (41.2%) evidenced instability in multiple tested microsatellite markers ranging from 3-7 and were defined as MI-positive patients. MI occurred more frequently...
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