Article
Elementary phenotypes in the neurobiological and genetic study of schizophrenia.
Biological psychiatry - 1 Jul 1999
Adler L E, Freedman R, Ross R G, Olincy A, Waldo M C
Abstract excerpt
This review describes the strategy of using elementary phenotypes for neurobiological and genetic linkage studies of schizophrenia. The review concentrates on practical aspects of selecting the phenotype and then understanding the confounds in its measurement and interpretation. Examples from the authors' studies of deficits in P50 inhibition and smooth pursuit eye movement dysfunction are presented. These two...
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