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Article

HLA-B27 has no effect on the phenotypic expression of progressive ankylosis in ank/ank mice.

The Journal of rheumatology - 1 May 2000

Krug H E, Taurog J D

Abstract excerpt

OBJECTIVE: To investigate whether HLA-B27 influences the expression of murine progressive ankylosis (MPA), a single-gene autosomal recessive mouse model of ankylosing spondylitis that arises in mice homozygous for the ank gene. METHODS: Mice transgenic for HLA-B27 were bred with ank/ank mice, and the phenotypes of the F1 and F2 progeny were observed. RESULTS: ank/+ mice showed no abnormalities, and ank/ank mice...

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PMID: 10813297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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