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Article

Suppressive interactions between mutations located in the two nucleotide binding domains of CFTR.

FEBS letters - 12 May 2000

Wei L, Vankeerberghen A, Jaspers M, Cassiman J, Nilius B, Cuppens H

Abstract excerpt

The S1235R locus in CFTR was studied in combination with alleles found at the M470V and G628R loci. While R628 caused a maturational defect, R1235 did not. The impact of R1235 was found to be influenced by the alleles present at the G628R and M470V loci. At the single channel level, R1235-V (R1235 on a V470 background) was characterized by an open probability significantly higher than V470-wildtype CFTR. M470,...

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Source

Identifiers

PMID: 10812063
DOI: 10.1016/s0014-5793(00)01519-2

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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