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Article

Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants.

The Biochemical journal - 1 Sept 2007

Wang Ying, Loo Tip W, Bartlett M Claire, Clarke David M

Abstract excerpt

The most common cause of CF (cystic fibrosis) is the deletion of Phe(508) (DeltaF508) in the CFTR [CF TM (transmembrane) conductance regulator] chloride channel. One major problem with DeltaF508 CFTR is that the protein is defective in folding so that little mature protein is delivered to the cel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17535157
DOI: 10.1042/BJ20070478
PMCID: PMC1948964

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17535157-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants.PMID 17535157Read ↗

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Modulating the folding of P-glycoprotein and cystic fibrosis transmembrane conductance regulator truncation mutants with pharmacological chaperones.Semantic proximity Read ↗

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A chemical corrector modifies the channel function of F508del-CFTR.Semantic proximity Read ↗

Correctors promote folding of the CFTR in the endoplasmic reticulum.Semantic proximity Read ↗

Processing mutations disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR).Semantic proximity Read ↗

Rescue of functional DeltaF508-CFTR channels by co-expression with truncated CFTR constructs in COS-1 cells.Semantic proximity Read ↗

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