Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Smad1 and Smad4 are components of the bone morphogenetic protein-4 (BMP-4)-induced transcription complex of the Xvent-2B promoter.

The Journal of biological chemistry - 21 Jul 2000

Henningfeld K A, Rastegar S, Adler G, Knöchel W

Abstract excerpt

To study the mechanism of transcriptional activation of the Xenopus homeobox gene Xvent-2B, we have delineated the bone morphogenetic protein-4 (BMP-4)-responsive region between -275/-152 in the proximal promoter. Consistent with the BMP-4 inductive nature of this region, this element exhibits transcriptional activation upon ectopic expression of Smad1 and Smad4. Electrophoretic mobility shift assays with total...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 4
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Growth Factors

Share to Smad Proteins

Share to Smad4 Protein

Share to Transcriptional Activation

Share to Xenopus

Share to Xenopus Proteins

Source

Identifiers

PMID: 10791953
DOI: 10.1074/jbc.M000978200

Genes

GCAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Smad1 and Smad4 are components of the bone morphogenetic protein-4 (BMP-4)-induced transcription complex of the Xvent-2B promoter.PMID 10791953Read ↗

Direct response elements of BMP within the PV.1A promoter are essential for its transcriptional regulation during early Xenopus development.Semantic proximity Read ↗

Transcriptional regulation of Xvent homeobox genes.Semantic proximity Read ↗

Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 PromoterSemantic proximity Read ↗

Characterization of a bone morphogenetic protein-responsive Smad-binding element.Semantic proximity Read ↗

XBP1 forms a regulatory loop with BMP-4 and suppresses mesodermal and neural differentiation in Xenopus embryos.Semantic proximity Read ↗

Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus.Semantic proximity Read ↗

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding ProteinSemantic proximity Read ↗

Cloning and characterization of zebrafish smad2, smad3 and smad4.Semantic proximity Read ↗

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motifSemantic proximity Read ↗

An extensive 3' regulatory region controls expression of Bmp5 in specific anatomical structures of the mouse embryo.Semantic proximity Read ↗

Induction of Platelet-derived Growth Factor B-chain Expression by Transforming Growth Factor-β Involves Transactivation by SmadsSemantic proximity Read ↗

TGFβ and BMP-2 Activation of the OPN Promoter: Roles of Smad- and Hox-Binding ElementsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.