Article
KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy.
Trends in neurosciences - 1 Sept 2000
Rogawski M A
Abstract excerpt
In 1998, the discovery of two novel genes KCNQ2 and KCNQ3, mutated in a rare inherited form of epilepsy known as benign familial neonatal convulsions, for the first time enabled insight into the molecular etiology of a human idiopathic generalized epilepsy syndrome. These disease genes encode subunits of neuronal M-type K+ channels, key regulators of brain excitability. Analogies between benign familial neonatal...
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