Article
The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3.
FEBS letters - 6 Nov 1998
Tinel N, Lauritzen I, Chouabe C, Lazdunski M, Borsotto M
Abstract excerpt
Benign familial neonatal convulsions, an autosomal dominant epilepsy of newborns, are linked to mutations affecting two six-transmembrane potassium channels, KCNQ2 and KCNQ3. We isolated four splice variants of KCNQ2 in human brain. Two forms generate, after transient expression in COS cells, a p...
Topics
- Aging
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Benzodiazepines
- Brain
- COS Cells
- Gene Expression Regulation
- Gene Expression Regulation, Developmental
- Genetic Variation
- Humans
- In Situ Hybridization
- KCNQ2 Potassium Channel
- KCNQ3 Potassium Channel
- Mice
- Molecular Sequence Data
- Organ Specificity
- Potassium Channels