Article
Functional phenotype in transgenic mice expressing mutant human presenilin-1.
Neurobiology of disease - 1 Apr 2000
Barrow P A, Empson R M, Gladwell S J, Anderson C M, Killick R, Yu X, Jefferys J G, Duff K
Abstract excerpt
Mutations in the presenilin-1 (PS1) gene cause approximately 50% of cases of early onset familial Alzheimer's disease. The function of this protein remains unknown. We have made an electrophysiological study of hippocampal slices from transgenic mice expressing either a normal human PS1 transgene (WT) or one of two human PS1 transgenes bearing pathogenic mutations at codon M146 (M146L and M146V). Medium and late...
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