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Article

Presenilin 1 mutation decreases both calcium and contractile responses in cerebral arteries.

Neurobiology of aging - 1 Oct 2017

Toussay Xavier, Morel Jean-Luc, Biendon Nathalie, Rotureau Lolita, Legeron François-Pierre, Boutonnet Marie-Charlotte, Cho Yoon H, Macrez Nathalie

Abstract excerpt

Mutations or upregulation in presenilin 1 (PS1) gene are found in familial early-onset Alzheimer's disease or sporadic late-onset Alzheimer's disease, respectively. PS1 has been essentially studied in neurons and its mutation was shown to alter intracellular calcium (Ca2+) signals. Here, we showed that PS1 is expressed in smooth muscle cells (SMCs) of mouse cerebral arteries, and we assessed the effects of the...

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PMID: 28753475
DOI: 10.1016/j.neurobiolaging.2017.06.015

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