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Article

Regulation and role of IFN-gamma in the innate resistance to infection with Chlamydia pneumoniae.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2000

Rottenberg M E, Gigliotti Rothfuchs A, Gigliotti D, Ceausu M, Une C, Levitsky V, Wigzell H

Abstract excerpt

By using mice genomically lacking IFN-gammaR, IL-12, perforin, and recombination-activating gene-1 (RAG-1), we analyzed the regulation and importance of IFN-gamma in the control of infection with Chlamydia pneumoniae. IL-12 participates in resistance of mice to C. pneumoniae, probably by regulating the protective levels of IFN-gamma mRNA. In turn, IFN-gamma is necessary for the increased IL-12p40 mRNA...

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Identifiers

PMID: 10779789
DOI: 10.4049/jimmunol.164.9.4812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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