Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complement depletion facilitates the infection of multiple brain tumors by an intravascular, replication-conditional herpes simplex virus mutant.

Journal of virology - 1 May 2000

Ikeda K, Wakimoto H, Ichikawa T, Jhung S, Hochberg F H, Louis D N, Chiocca E A

Abstract excerpt

Intravascular routes of administration can provide a means to target gene- and virus-based therapies to multiple tumor foci located within an organ, such as the brain. However, we demonstrate here that rodent plasma inhibits cell transduction by replication-conditional (oncolytic) herpes simplex viruses (HSV), replication-defective HSV, and adenovirus vectors. In vitro depletion of complement with mild heat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Complement System Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclophosphamide

Share to Gene Transfer Techniques

Share to Herpes Simplex

Share to Rats, Nude

Share to Simplexvirus

Share to Virus Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 10775615
DOI: 10.1128/jvi.74.10.4765-4775.2000
PMCID: PMC111999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complement depletion facilitates the infection of multiple brain tumors by an intravascular, replication-conditional herpes simplex virus mutant.PMID 10775615Read ↗

Complement Inhibition Prevents Oncolytic Vaccinia Virus Neutralization in Immune Humans and Cynomolgus MacaquesSemantic proximity Read ↗

Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vectorSemantic proximity Read ↗

Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil.Semantic proximity Read ↗

Antibodies against the capsid induced after intracranial AAV administration limits second administration in a dose dependent mannerSemantic proximity Read ↗

Immuno-viral therapy as a new approach for the treatment of brain tumors.Semantic proximity Read ↗

Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207).Semantic proximity Read ↗

Viral shedding and biodistribution of G207, a multimutated, conditionally replicating herpes simplex virus type 1, after intracerebral inoculation in aotus.Semantic proximity Read ↗

Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats.Semantic proximity Read ↗

Neural precursor cells for delivery of replication-conditional HSV-1 vectors to intracerebral gliomas.Semantic proximity Read ↗

Serial passage through human glioma xenografts selects for a Deltagamma134.5 herpes simplex virus type 1 mutant that exhibits decreased neurotoxicity and prolongs survival of mice with experimental brain tumors.Semantic proximity Read ↗

Therapeutic Efficiency and Safety of a Second-Generation Replication-Conditional HSV1 Vector for Brain Tumor Gene TherapySemantic proximity Read ↗

Novel Immunocompetent Murine Tumor Model for Evaluation of Conditionally Replication-Competent (Oncolytic) Murine Adenoviral VectorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.