Article
K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
The Tohoku journal of experimental medicine - 1 Oct 1999
Tanoguchi K, Yaegashi N, Jiko K, Maekawa A, Sato S, Yajima A
Abstract excerpt
The Donryu rat has been found to have a high incidence of spontaneous uterine endometrial carcinomas. Moreover the histologic findings, biological nature and pathogenesis of these rat tumors appear similar to those in humans. To determine if the incidence of H- and K-ras gene mutations in these rat tumors is similar to that in human endometrial cancers, we isolated DNA samples from 2 atypical hyperplasias, 5...
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