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Article

Pacing a small cage: mutation and RNA viruses.

Trends in ecology & evolution - 1 Apr 2008

Belshaw Robert, Gardner Andy, Rambaut Andrew, Pybus Oliver G

Abstract excerpt

RNA viruses have an extremely high mutation rate, and we argue that the most plausible explanation for this is a trade-off with replication speed. We suggest that research into further increasing this mutation rate artificially as an antiviral treatment requires a theoretical reevaluation, especially relating to the so-called error threshold. The main evolutionary consequence of a high mutation rate appears to...

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Identifiers

PMID: 18295930
DOI: 10.1016/j.tree.2007.11.010
PMCID: PMC7125972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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