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Article

Changes in insulin-like growth factor signaling alter phenotypes in Fragile X Mice.

Genes, brain, and behavior - 1 Feb 2017

Wise T L

Abstract excerpt

Fragile X syndrome (FXS) is an inherited form of intellectual disability that is usually caused by expansion of a polymorphic CGG repeat in the 5' untranslated region of the X-linked FMR1 gene, which leads to hypermethylation and transcriptional silencing. Two non-neurological phenotypes of FXS are enlarged testes and connective tissue dysplasia, which could be caused by alterations in a growth factor signaling...

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Share to Disease Models, Animal
Share to DNA Methylation
Share to Fragile X Mental Retardation Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Knockout

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Source

Identifiers

PMID: 27643697
DOI: 10.1111/gbb.12340

Genes

FMR1
IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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