Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase.

doi:10.1074/jbc.273.43.28238

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Article

Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase.

The Journal of biological chemistry - 23 Oct 1998

Adam L, Vadlamudi R, Kondapaka S B, Chernoff J, Mendelsohn J, Kumar R

Abstract excerpt

The mechanisms through which heregulin (HRG) regulates the activities of breast cancer cells are currently unknown. We demonstrate that HRG stimulation of noninvasive breast cancer cells enhanced the conversion of globular to filamentous actin and the formation of membrane ruffles, stress fibers,...

Topics

Actins
Breast Neoplasms
Carrier Proteins
Cell Movement
Cytoskeleton
Enzyme Activation
ErbB Receptors
Female
Gene Expression
Glycoproteins
Humans
Keratins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Morphogenesis

Mutation

Neoplasm Invasiveness

Neuregulin-1

Phosphatidylinositol 3-Kinases

Protein Binding

Source

Open in PubMed

Identifiers

PMID: 9774445
DOI: 10.1074/jbc.273.43.28238

Genes

HRG
PAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9774445-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase.PMID 9774445Read ↗

Heregulin regulates the actin cytoskeleton and promotes invasive properties in breast cancer cell lines.Semantic proximity Read ↗

Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability.Semantic proximity Read ↗

Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.Semantic proximity Read ↗

Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells.Semantic proximity Read ↗

Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1.Semantic proximity Read ↗

H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3.Semantic proximity Read ↗

Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells.Semantic proximity Read ↗

Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis.Semantic proximity Read ↗

Actin Filaments at the Leading Edge of Cancer Cells Are Characterized by a High Mobile Fraction and Turnover Regulation by Profilin ISemantic proximity Read ↗

PAK-dependent regulation of actin dynamics in breast cancer cellsSemantic proximity Read ↗

FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration.Semantic proximity Read ↗

A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cellsSemantic proximity Read ↗

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