Article
Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1.
The Journal of biological chemistry - 7 Jul 2000
Chatterjee-Kishore M, van Den Akker F, Stark G R
Abstract excerpt
The LMP2 gene, which encodes a protein required for efficient presentation of viral antigens, requires both unphosphorylated Stat1 and IRF1 for basal expression. LMP2 expression is down-regulated by the adenovirus protein E1A, which binds to Stat1 and CBP/p300, and by the mutant E1A protein RG2, which binds to Stat1 but not to CBP/p300, but not by the mutant protein Delta2-36, which does not bind to either Stat1...
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