Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epstein-Barr virus LMP2A suppresses MHC class II expression by regulating the B-cell transcription factors E47 and PU.1

29 Jan 2015

Abstract excerpt

Oncogenic Epstein-Barr virus (EBV) uses various approaches to escape host immune responses and persist in B cells. Such persistent infections may provide the opportunity for this virus to initiate tumor formation. Using EBV-immortalized lymphoblastoid cell lines (LCLs) as a model, we found that the expression of major histocompatibility complex (MHC) class II and CD74 in B cells is repressed after EBV infection....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histiocytic Disorders and Treatments
Share to Parvovirus B19 Infection Studies
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25631773
DOI: 10.1182/blood-2014-08-594689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epstein-Barr virus LMP2A suppresses MHC class II expression by regulating the B-cell transcription factors E47 and PU.1PMID 25631773Read ↗

Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T CellsSemantic proximity Read ↗

Epstein-Barr Virus LMP2A Interferes with Global Transcription Factor Regulation When Expressed during B-Lymphocyte DevelopmentSemantic proximity Read ↗

Epstein-Barr Virus Evades CD4+ T Cell Responses in Lytic Cycle through BZLF1-mediated Downregulation of CD74 and the Cooperation of vBcl-2Semantic proximity Read ↗

The effects of the Epstein-Barr virus latent membrane protein 2A on B cell function.Semantic proximity Read ↗

NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1Semantic proximity Read ↗

Evasion of affinity-based selection in germinal centers by Epstein–Barr virus LMP2ASemantic proximity Read ↗

The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype.Semantic proximity Read ↗

The Lytic Cycle of Epstein-Barr Virus Is Associated with Decreased Expression of Cell Surface Major Histocompatibility Complex Class I and Class II MoleculesSemantic proximity Read ↗

Epstein-Barr virus nuclear antigen 2 inhibits AID expression during EBV-driven B-cell growthSemantic proximity Read ↗

Genome-Wide Expression Profiling Reveals EBV-Associated Inhibition of MHC Class I Expression in Nasopharyngeal CarcinomaSemantic proximity Read ↗

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.Semantic proximity Read ↗

Role of the Immunoreceptor Tyrosine-Based Activation Motif of Latent Membrane Protein 2A (LMP2A) in Epstein-Barr Virus LMP2A-Induced Cell TransformationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.