Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP17 promotor polymorphism and ovarian cancer risk.

International journal of cancer - 1 May 2000

Spurdle A B, Chen X, Abbazadegan M, Martin N, Khoo S K, Hurst T, Ward B, Webb P M, Chenevix-Trench G

Abstract excerpt

The CYP17 gene encodes the cytochrome P450c17alpha enzyme, which functions at 2 different points in the steroid biosynthesis pathway, and is considered a candidate susceptibility gene for endocrine-related tumors. A T to C substitution polymorphism exists in the 5' promoter region of this gene, and creates an additional Sp1-type motif. Several studies have examined this polymorphism as a risk factor for breast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Alleles
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ovarian Neoplasms

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Steroid 17-alpha-Hydroxylase

Source

Identifiers

PMID: 10760835
DOI: 10.1002/(sici)1097-0215(20000501)86:3<436::aid-ijc21>3.0.co;2-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP17 promotor polymorphism and ovarian cancer risk.PMID 10760835Read ↗

CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. a HuGE review.Semantic proximity Read ↗

CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1.Semantic proximity Read ↗

CYP17 promoter polymorphism and breast cancer risk in males and females in relation to BRCA2 status.Semantic proximity Read ↗

Genetic variation in CYP17 and endometrial cancer risk.Semantic proximity Read ↗

Genetic variation of the CYP17 and susceptibility to endometrial cancer: a meta-analysis.Semantic proximity Read ↗

Association between CYP17 gene polymorphism and risk of breast cancer in young women.Semantic proximity Read ↗

The T/C polymorphism of the CYP17 gene and G/A polymorphism of the CYP19 gene in endometrial cancer.Semantic proximity Read ↗

Cytochrome P450c17alpha 5'-untranslated region *T/C polymorphism in endometriosis.Semantic proximity Read ↗

CYP17 gene polymorphism in relation to breast cancer risk: a case-control study.Semantic proximity Read ↗

Association between CYP17 polymorphisms and the development of breast cancer.Semantic proximity Read ↗

CYP17 genotype and ovarian cancer: a null case-control study.Semantic proximity Read ↗

No association of the 5' promoter region polymorphism of CYP17 gene with prostate cancer risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.