Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A role for the Hsp40 Ydj1 in repression of basal steroid receptor activity in yeast.

Molecular and cellular biology - 1 May 2000

Johnson J L, Craig E A

Abstract excerpt

In addition to its roles in translocation of preproteins across membranes, Ydj1 facilitates the maturation of Hsp90 substrates, including mammalian steroid receptors, which activate transcription in yeast in a hormone-dependent manner. To better understand Ydj1's function, we have constructed and analyzed an array of Ydj1 mutants in vivo. Both the glucocorticoid receptor and the estrogen receptor exhibited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Galactosidase
Share to Genes, src
Share to HSP40 Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HSP70 Heat-Shock Proteins

Share to HSP90 Heat-Shock Proteins

Share to Receptors, Glucocorticoid

Share to Receptors, Steroid

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 10757787
DOI: 10.1128/MCB.20.9.3027-3036.2000
PMCID: PMC85575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role for the Hsp40 Ydj1 in repression of basal steroid receptor activity in yeast.PMID 10757787Read ↗

Domain requirements of DnaJ-like (Hsp40) molecular chaperones in the activation of a steroid hormone receptor.Semantic proximity Read ↗

Farnesylation of Ydj1 is required for in vivo interaction with Hsp90 client proteins.Semantic proximity Read ↗

Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function.Semantic proximity Read ↗

Mutations in the yeast Hsp40 chaperone protein Ydj1 cause defects in Axl1 biogenesis and pro-a-factor processing.Semantic proximity Read ↗

Overexpression of yeast Hsp110 homolog Sse1p suppresses ydj1-151 thermosensitivity and restores Hsp90-dependent activity.Semantic proximity Read ↗

The molecular chaperone Hsp90 mediates heme activation of the yeast transcriptional activator Hap1.Semantic proximity Read ↗

Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction.Semantic proximity Read ↗

Hsp90 mutants disrupt glucocorticoid receptor ligand binding and destabilize aporeceptor complexes.Semantic proximity Read ↗

The type I Hsp40 zinc finger-like region is required for Hsp70 to capture non-native polypeptides from Ydj1.Semantic proximity Read ↗

A highly efficient and sensitive screening method for trans-activation activity of estrogen receptors.Semantic proximity Read ↗

Probing the structure and function of the estrogen receptor ligand binding domain by analysis of mutants with altered transactivation characteristics.Semantic proximity Read ↗

Yeast Asc1p and mammalian RACK1 are functionally orthologous core 40S ribosomal proteins that repress gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.